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G 573
CAS No. 22868-35-5
G 573( G573 )
Catalog No. M13632 CAS No. 22868-35-5
G 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM; blocks MEK phosphorylation by BRAF(V600E).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameG 573
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NoteResearch use only, not for human use.
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Brief DescriptionG 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM; blocks MEK phosphorylation by BRAF(V600E).
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DescriptionG 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM; blocks MEK phosphorylation by BRAF(V600E), and stabilizes the RAF-MEK complex; inhibits the proliferation of A375 (BRAF V600E) with IC50 of 11 nM, 15-fold less potent for HCT116 (KRAS G13D).
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In Vitro——
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In Vivo——
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SynonymsG573
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK
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Research Area——
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Indication——
Chemical Information
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CAS Number22868-35-5
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Formula Weight228.68
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Molecular FormulaC13H9ClN2
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Purity>98% (HPLC)
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Solubility——
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SMILESClC1=CC(C2=NC3=CC=CC=C3N2)=CC=C1
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Chemical Name2-(3-Chlorophenyl)-1H-benzimidazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hatzivassiliou G, et al. Nature. 2013 Sep 12;501(7466):232-6.
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